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Structure-Function relationships of equine menisci.

Iris Ribitsch¹, Christian Peham¹, Nicole Ade^1,2

¹Department for Companion Animals and Horses, Veterm, University Equine Hospital, Vetmeduni Vienna, Vienna, Vienna, Austria.

|March 10, 2018

Summary

This summary is machine-generated.

Equine knee meniscus exhibits age and site-specific changes in hardness, crucial for understanding joint injuries. These findings support horses as a valuable model for human meniscus research and tissue engineering.

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Area of Science:

Comparative biomechanics
Veterinary orthopedics
Tissue engineering

Background:

Meniscal pathologies are common in humans and horses, with equine medial meniscus injuries mirroring human posterior medial horn injuries.
Human meniscus biomechanics are site- and depth-specific, but equine meniscus properties remain largely uncharacterized.
Understanding equine meniscus biomechanics can improve veterinary treatments and validate horses as a translational model for human meniscus research.

Purpose of the Study:

To investigate site- and age-specific composition, structure, and biomechanical properties of the equine knee meniscus.
To explore the relationship between equine meniscus topography, composition, and biomechanical characteristics.
To assess the suitability of the equine meniscus as a model for human meniscus tissue engineering.

Main Methods:

Histological examination of meniscus architecture.
Biomechanical testing, including shore hardness (SH), stiffness, and energy loss measurements.
Site-specific and age-specific analysis of collected data.

Main Results:

Shore hardness (SH) demonstrated significant age and site-specific variations.
The tibial meniscus surface exhibited higher SH, which increased with age.
Stiffness and energy loss did not show significant site or age-related differences.
Macroscopic and histologic similarities were observed between equine and human menisci.

Conclusions:

Equine meniscus exhibits distinct age and site-specific biomechanical properties, particularly in hardness.
The findings support the use of horses as a translational model for human meniscus research and tissue engineering.
Further research is warranted given the observed similarities between equine and human menisci.