Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defenses Against Pathogens and Herbivores02:26

Defenses Against Pathogens and Herbivores

29.7K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.9K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.9K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.1K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.1K
Antibiotic Selection00:57

Antibiotic Selection

60.2K
Overview
60.2K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.6K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-enabled discovery of antibiotics effective against <i>Neisseria gonorrhoeae</i>.

Science translational medicine·2026
Same author

[Towards improved sepsis management : AI as a tool for clinicians].

Revue medicale suisse·2026
Same author

Generative AI for synthetic biology: Designing biological parts, circuits, and genomes.

Cell systems·2026
Same author

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling.

Nature communications·2026
Same author

Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature.

Journal de mycologie medicale·2026
Same author

An artificial intelligence-powered learning health system to improve sepsis detection and quality of care: a before-and-after study.

NPJ digital medicine·2026

Related Experiment Video

Updated: Feb 13, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens
10:39

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

14.1K

Targeting Antibiotic Tolerance, Pathogen by Pathogen.

Sylvain Meylan1, Ian W Andrews2, James J Collins3

  • 1Department of Biomedicine, Basel University Hospital, Basel, CH-4031, Switzerland; Division of Infectious Diseases and Hospital Epidemiology, Basel University Hospital, Basel, CH-4031, Switzerland; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

Cell
|March 10, 2018
PubMed
Summary
This summary is machine-generated.

Antibiotic tolerance allows bacteria to survive antibiotics, increasing infection severity. Understanding pathogen-specific tolerance mechanisms is key to developing targeted therapies against drug-resistant infections.

More Related Videos

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.8K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

4.4K

Related Experiment Videos

Last Updated: Feb 13, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens
10:39

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

14.1K
Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.8K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

4.4K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic tolerance, where susceptible bacteria survive antibiotic exposure, significantly contributes to persistent bacterial infections.
  • The clinical impact of antibiotic tolerance is often underestimated, despite its role in treatment failure.

Purpose of the Study:

  • To examine the clinical significance of antibiotic tolerance using a pathogen-specific approach.
  • To explore how pathogen physiology within infection environments influences antibiotic tolerance mechanisms.
  • To highlight novel therapeutic strategies and experimental platforms for combating drug-tolerant bacteria.

Main Methods:

  • Pathogen-by-pathogen analysis of antibiotic tolerance.
  • Investigation of pathogen physiology in infection settings.
  • Development of species-specific therapeutic strategies.
  • Utilizing experimental platforms for in vivo studies of drug-tolerant pathogens.

Main Results:

  • Antibiotic tolerance is a critical factor in bacterial disease burden.
  • Pathogen-specific physiology directly impacts the mechanisms of antibiotic tolerance.
  • Insights are driving the creation of targeted treatments for antibiotic tolerance.

Conclusions:

  • Targeting antibiotic tolerance is crucial for effective treatment of bacterial infections.
  • Understanding pathogen-specific tolerance mechanisms is essential for developing new therapies.
  • Advanced experimental models are improving our comprehension of drug-tolerant pathogens in vivo.