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Pattern recognition receptors in fungal immunity

Emmanuel C Patin1, Aiysha Thompson1, Selinda J Orr1

  • 1Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom.

Seminars in Cell & Developmental Biology
|March 10, 2018
PubMed

Insights

Invasive fungal infections are a growing threat. Understanding pattern recognition receptors (PRRs) in host-pathogen interactions offers new immunotherapy strategies against fungi.

Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Invasive fungal infections pose a significant global health challenge, necessitating novel therapeutic approaches.
  • Host-pathogen interactions are crucial for understanding and combating fungal diseases.
  • Antigen-presenting cells, like macrophages and dendritic cells, are key players in innate immunity against fungi.

Purpose of the Study:

  • To review current knowledge on pattern recognition receptors (PRRs) involved in fungal recognition.
  • To explore PRR collaboration, signaling regulation, and their role in antifungal immunity.
  • To discuss the application of PRR biology, particularly Dectin-1, in developing new antifungal immunotherapies.

Main Methods:

  • Literature review of recent findings on PRR biology and function in fungal recognition.
  • Analysis of studies on PRR crosstalk and signaling inhibition mechanisms.
  • Examination of research translating PRR knowledge into immunotherapy strategies.

Main Results:

  • PRRs are essential for sensing fungal pathogens and initiating innate immune responses.
  • PRR signaling pathways are complex, involving collaboration and intricate regulatory mechanisms.
  • Targeting PRRs, especially Dectin-1, shows promise for novel antifungal immunotherapies.

Conclusions:

  • Advances in understanding PRRs offer new avenues for treating invasive fungal infections.
  • Targeting host-pathogen interactions via PRR modulation is a promising strategy for antifungal drug development.
  • Further research into PRR biology will facilitate the design of effective immunotherapies against fungal threats.
Keywords:
C-type lectin-like receptorCrosstalkNod-like receptorPathogen recognition receptorToll-like receptor

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