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Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
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Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control

Published on: April 11, 2013

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Oxidative responses and fungal infection biology

Adilia Warris1, Elizabeth R Ballou2

  • 1Medical Research Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.

Seminars in Cell & Developmental Biology
|March 10, 2018
PubMed

Insights

Fungi and hosts maintain a balance of reactive oxygen and nitrogen species during infection. This review explores how fungi overcome host defenses through stress responses in pathogenesis.

Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Host-pathogen interactions are crucial in infectious diseases.
  • Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key mediators of host defense.
  • Fungal pathogens have evolved mechanisms to counteract host immunity.

Purpose of the Study:

  • To review emerging themes in fungal pathogenesis.
  • To describe the axis of host-pathogen interaction involving ROS and RNS.
  • To highlight fungal stress responses.

Main Methods:

  • Literature review of recent studies on fungal pathogenesis.
  • Analysis of host-pathogen interaction mechanisms.
  • Synthesis of information on fungal stress responses.

Main Results:

  • Fungal stress responses are critical for survival and virulence.
  • The balance of ROS and RNS production influences infection outcome.
  • Emerging themes in pathogenesis are identified.

Conclusions:

  • Understanding the interplay between host ROS/RNS and fungal stress responses is vital.
  • This axis represents a significant area for therapeutic intervention.
  • Further research into fungal pathogenesis mechanisms is warranted.
Keywords:
Fungal infection biologyFungiNADPH-oxidaseOxidative stressReactive nitrogen speciesReactive oxygen species

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