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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
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Exogenous 8-Oxo-7,8-dihydro-2'-deoxyguanosine: Biomedical Properties, Mechanisms of Action, and Therapeutic Potential

A V Chernikov1, S V Gudkov, A M Usacheva

  • 1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia. anatole@inbox.ru.

Biochemistry. Biokhimiia
|March 11, 2018
PubMed

Insights

8-Oxo-7,8-dihydroguanine (8-oxo-G), a marker of DNA oxidative damage, actively participates in cellular signaling. This review explores its role in stress responses and potential therapeutic applications for inflammatory diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • 8-Oxo-7,8-dihydroguanine (8-oxo-G) is a well-established biomarker for DNA oxidative damage.
  • Emerging research reveals 8-oxo-G's active role in intracellular signaling, beyond DNA repair byproducts.

Purpose of the Study:

  • To review the signaling functions of free 8-oxo-G and oxidized DNA.
  • To explore the therapeutic potential of 8-oxo-G and related molecules in diseases linked to inflammation and oxidative stress.

Main Methods:

  • Systematization of existing experimental data.
  • Analysis of molecular mechanisms of oxidized guanine action.

Main Results:

  • Free 8-oxo-G and oxidized extracellular DNA act as stress signaling mediators, initiating inflammatory and immune responses.
  • Exogenous 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) demonstrates significant anti-inflammatory and antioxidant effects.

Conclusions:

  • Oxidized guanine derivatives play dual roles in cellular signaling and immune response.
  • Targeting 8-oxo-G pathways offers therapeutic prospects for inflammatory and oxidative stress-related diseases.

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