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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Pediatric multiple sclerosis: a review.

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  • 1Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041, Sharq, Kuwait. alroughani@gmail.com.

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|March 11, 2018
PubMed
Summary
This summary is machine-generated.

Pediatric-onset multiple sclerosis (MS) is increasingly diagnosed. This review guides physicians on diagnosing and managing pediatric MS, highlighting its inflammatory nature and treatment challenges while awaiting new therapies.

Keywords:
Acute disseminated encephalomyelitisClinically isolated syndromeMultiple sclerosisNeuromyelitis opticsPediatric multiple sclerosis

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Area of Science:

  • Neurology
  • Pediatrics
  • Immunology

Background:

  • Global prevalence and incidence of pediatric-onset multiple sclerosis (POMS) are rising.
  • No disease-modifying therapies are currently approved for pediatric MS.
  • Physicians require updated guidance on POMS diagnosis and management.

Purpose of the Study:

  • To review the current literature on pediatric-onset multiple sclerosis (POMS).
  • To provide guidance for physicians on the diagnosis and management of pediatric MS.
  • To discuss challenges in assessing and implementing diagnosis and therapy in clinical practice.

Main Methods:

  • Comprehensive literature search.
  • Review of current understanding of risk factors and disease parameters in pediatric MS.
  • Discussion of diagnostic and therapeutic challenges.

Main Results:

  • Revised diagnostic criteria enhance accuracy; identifying red flags and mimickers is crucial.
  • Pediatric MS often presents with active inflammation and infratentorial symptoms.
  • While adult data informs treatment, pediatric-specific randomized trials for oral therapies are ongoing.

Conclusions:

  • Pediatric MS is recognized as having a more inflammatory course with frequent infratentorial onset.
  • This understanding impacts future management strategies for pediatric cohorts.
  • Ongoing clinical trials are expected to yield crucial therapeutic data.