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Published on: July 14, 2021
Association of serum ADAMTS-7 levels with left ventricular reverse remodeling after ST-elevation myocardial
Wenjing Wu1, Jiahui Li1, Changan Yu1
1Department of Cardiology, China-Japan Friendship Hospital, Beijing, 100029, China.
Insights
Serum levels of ADAMTS-7, a protein, can predict left ventricular reverse remodeling (LVRR) after ST-elevation myocardial infarction (STEMI). A significant drop in ADAMTS-7 from day 1 to day 7 post-STEMI indicates a higher likelihood of LVRR.
Area of Science:
- Cardiology
- Biomarkers
- Myocardial Infarction Research
Background:
- Left ventricular reverse remodeling (LVRR) post-ST-elevation myocardial infarction (STEMI) is a positive prognostic indicator.
- Serum levels of ADAMTS-7 are being explored as potential prognostic markers for STEMI patients.
Purpose of the Study:
- To investigate the association between serum ADAMTS-7 levels and LVRR in STEMI patients.
- To determine if ADAMTS-7 can serve as a predictive biomarker for LVRR.
Main Methods:
- Prospective study involving 104 STEMI patients and 63 controls.
- Serum ADAMTS-7 levels measured at multiple time points post-STEMI (days 1, 3, 7; months 1, 6).
- LVRR defined as a ≥15% decrease in left ventricular end-systolic volume at 6 months.
Main Results:
- Lower serum ADAMTS-7 levels were observed in patients with LVRR compared to those without LVRR at 7 days post-STEMI (p=0.032).
- A significant decrease in ADAMTS-7 from day 1 to day 7 (ΔADAMTS-7) was notably lower in the LVRR group (p=0.021).
- Multivariate analysis confirmed ΔADAMTS-7 (day 7 minus day 1) as an independent predictor of LVRR (OR=-0.322, p=0.028).
Conclusions:
- The change in serum ADAMTS-7 levels from day 1 to day 7 post-STEMI (ΔADAMTS-7) shows promise as a predictive factor for LVRR.
- ROC curve analysis indicated that ΔADAMTS-7 < -0.39 could predict LVRR with high sensitivity (89%) and specificity (82%).
Background:
Left ventricular reverse remodeling (LVRR) in patients with ST-elevation myocardial infarction (STEMI) is associated with a good prognosis. Serum levels of ADAMTS-7 might be used for the prognosis of STEMI. This study aimed to investigate the relationship between serum ADAMTS-7 levels and LVRR.
Methods:
This was a prospective study of 104 patients with STEMI who underwent revascularization and 63 controls. ADAMTS-7 serum levels were measured on days 1, 3, and 7 and in months 1 and 6 after STEMI. A decrease ≥ 15% of the left ventricular end-systolic volume at 6 months was defined as LVRR.
Results:
The serum levels of ADAMTS-7 in patients with LVRR were lower than those without LVRR (3.84 ± 2.26 vs. 5.02 ± 2.54, P = 0.032) 7 days after STEMI and the difference between day 7 and day 1 (ΔADAMTS-7) was even significantly lower (- 1.31 ± 0.94 vs. - 0.30 ± 0.22, P = 0.021). Multivariate analysis showed that ΔADAMTS-7(day 7 minus day 1) was independently associated with LVRR (OR = - 0.322, 95% CI = - 0.996 to - 0.074, P = 0.028). Receiver operating characteristic (ROC) curve analysis showed that LVRR could be predicted (sensitivity 89%, specificity 82%, and area under the curve 0.896) when ΔADAMTS-7(day 7 minus day 1) was < - 0.39.
Conclusions:
ΔADAMTS-7(day 7 minus day 1) might be a potential predictive factor for LVRR.
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