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Individualized controlled ovarian stimulation in expected poor-responders: an update
Thor Haahr1, Sandro C Esteves1,2,3, Peter Humaidan4
1Department of Clinical Medicine, Aarhus University, Denmark and the Fertility Clinic Skive, Skive Regional Hospital, Skive, Denmark.
Reproductive Biology and Endocrinology : RB&E
|March 11, 2018
Summary
Individualized treatment strategies are crucial for managing expected poor ovarian responders in assisted reproductive technology (ART). Tailoring ovarian stimulation protocols and adjuvant therapies improves outcomes for these challenging patients.
Area of Science:
- Reproductive Medicine
- Endocrinology
Background:
- Controlled ovarian stimulation is central to assisted reproductive technology (ART).
- Managing poor ovarian responders presents significant clinical challenges.
- Recent advances aid in defining and classifying expected poor responders.
Purpose of the Study:
- To review the classification of expected poor ovarian responders.
- To discuss efficacy measurements for controlled ovarian stimulation.
- To examine evidence for managing expected poor ovarian response, including adjuvant treatments.
Main Methods:
- Literature review focusing on classification, efficacy metrics, and adjuvant therapies for poor responders.
- Analysis of current evidence for individualized treatment approaches in ART.
Main Results:
- Individualized ovarian stimulation, considering ovarian reserve, BMI, and age, is supported by evidence.
- Improved classification of poor responders facilitates research into new treatment concepts.
- Adjuvant treatments like growth hormone, androgens, and LH activity show potential.
Conclusions:
- Individualized treatment is paramount for expected poor ovarian responders throughout all ART steps.
- This includes selecting GnRH analogues, gonadotropin type/dose, and ovulation triggers.
- Adjuvant therapies should be considered as part of personalized ART management.
Keywords:
ART calculatorAdjuvant therapyBologna criteriaControlled ovarian stimulationPoor ovarian responsePoseidon classificationMore Related Videos
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