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Related Concept Videos

Indicators02:39

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Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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Loading Drosophila Nerve Terminals with Calcium Indicators
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Indications for delivery in pre-eclampsia.

N Varnier1, M A Brown2, M Reynolds3

  • 1Department of Women's and Children's Health, St George Hospital, Kogarah, NSW, Australia.

Pregnancy Hypertension
|March 11, 2018
PubMed
Summary
This summary is machine-generated.

In late-onset pre-eclampsia, severe hypertension is the primary maternal trigger for delivery, significantly more common than fetal indicators like intrauterine growth restriction. Preterm delivery in pre-eclampsia is linked to more fetal complications.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Perinatology

Background:

  • Pre-eclampsia (PE) is a significant cause of maternal and fetal morbidity.
  • Delivery indicators in PE guide management, but their utilization varies.
  • Late-onset PE (delivery >32 weeks) is common and may have distinct management triggers.

Purpose of the Study:

  • To determine the frequency of accepted delivery indicators in pre-eclampsia.
  • To analyze maternal versus fetal triggers for delivery in a predominantly late-onset PE population.
  • To compare delivery triggers between preterm and term pre-eclampsia.

Main Methods:

  • Retrospective cohort study utilizing the St George Public Hospital Hypertension in Pregnancy database.
  • Extraction and verification of demographic, pregnancy, and outcome data.
  • Analysis of delivery triggers in 908 women with pre-eclampsia (2001-2013).

Main Results:

  • Severe hypertension was the most frequent maternal trigger (38%) in 303 women with available data.
  • Intrauterine growth restriction (IUGR) was the most common fetal trigger (4%).
  • Maternal triggers predominated overall, while fetal/combined triggers were more common in preterm PE (<37 weeks).

Conclusions:

  • Maternal factors, primarily severe hypertension, are the main drivers for delivery in late-onset pre-eclampsia.
  • Fetal indicators and combined maternal/fetal complications are more prevalent in preterm pre-eclampsia, suggesting greater placental dysfunction.
  • Understanding these trigger frequencies can optimize PE management strategies.