Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

51.9K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.9K
Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

16.9K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.9K
Bone Disorders01:29

Bone Disorders

5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
The Hyoid Bone01:12

The Hyoid Bone

5.3K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.3K
Spongy Bone01:09

Spongy Bone

8.2K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early- vs. late-onset gestational diabetes: Differential impact on maternal and neonatal outcomes.

Acta obstetricia et gynecologica Scandinavica·2026
Same author

Analysis of homocysteine levels in carriers with MMACHC gene variants.

Orphanet journal of rare diseases·2026
Same author

ROS-responsive hydrogel microspheres deliver shTMEM2-loaded liposomes to suppress pyroptosis and ameliorate intervertebral disc degeneration.

Journal of nanobiotechnology·2026
Same author

Ruxolitinib Penetrates Blood Brain Barrier and Reduces the Cytokine Storm in Patients With Haemophagocytic Lymphohistiocytosis.

Journal of cellular and molecular medicine·2026
Same author

Percutaneous endoscopic interlaminar discectomy in patients with lumbar disc herniation: risk factors and thresholds for adverse outcomes.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Clinical impact and predictive value of patient specific pre-bent rods in spinal deformity surgery: A comparative analysis of preoperative planned and postoperative outcomes.

Brain & spine·2026

Related Experiment Video

Updated: Feb 13, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
07:41

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

Published on: November 13, 2016

14.0K

Categorising bone defect hematomas - Enhance early bone healing.

Xin Wang1, Yi Zhang2, Wenjun Ji3

  • 1Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou, China; Joint Orthopaedic Research Center of Zunyi Medical University & University of Rochester Medical Center (JCMR-ZMU & URMC), Zunyi Medical University, Zunyi, 563000 Guizhou, China.

Medical Hypotheses
|March 11, 2018
PubMed
Summary

This study proposes a new hypothesis for bone healing, suggesting hematoma characteristics influence cell behavior and bone repair outcomes. Understanding these factors can improve healing in large bone defects.

More Related Videos

Author Spotlight: The Box-Cavity Cortical Approach for Enhanced Evaluation of Biomaterials and Bone Regeneration
02:56

Author Spotlight: The Box-Cavity Cortical Approach for Enhanced Evaluation of Biomaterials and Bone Regeneration

Published on: November 21, 2023

1.4K
Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
10:09

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

Published on: October 9, 2014

23.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
07:41

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

Published on: November 13, 2016

14.0K
Author Spotlight: The Box-Cavity Cortical Approach for Enhanced Evaluation of Biomaterials and Bone Regeneration
02:56

Author Spotlight: The Box-Cavity Cortical Approach for Enhanced Evaluation of Biomaterials and Bone Regeneration

Published on: November 21, 2023

1.4K
Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
10:09

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

Published on: October 9, 2014

23.3K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Fracture hematoma formation is a critical transitional phase in bone repair, involving complex interactions between fibrin, cells, and cytokines.
  • The differentiation of hematomas into fibrous tissues, leading to non-unions, is a significant challenge in treating critical-sized bone defects.

Purpose of the Study:

  • To propose a novel hypothesis explaining why hematomas in critical-sized bone defects often lead to fibrous tissue formation and non-unions.
  • To identify specific hematoma qualities that trigger cellular behaviors and influence the pattern of bone remodeling (intramembranous vs. endochondral ossification).

Main Methods:

  • The study proposes a hypothesis based on existing literature and proposes future research directions.
  • Detailed characterization of hematoma structural parameters is suggested as a key methodological approach.

Main Results:

  • The hypothesis posits that specific hematoma characteristics act as triggers for cellular responses.
  • Growth factor release patterns are hypothesized to dictate whether intramembranous or endochondral ossification prevails.

Conclusions:

  • Characterizing hematoma microenvironments can guide strategies to enhance mesenchymal stromal cell migration and accelerate bone healing.
  • This approach holds promise for managing complications associated with large, recalcitrant bone defects that resist natural healing.