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The pseudogene-derived long non-coding RNA SFTA1P suppresses cell proliferation, migration, and invasion in gastric

Hongwei Ma1,2, Tianshi Ma1, Miao Chen2

  • 1Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Bioscience Reports
|March 11, 2018
PubMed

Insights

Pseudogene-derived long non-coding RNAs (lncRNAs) like SFTA1P are key in gastric cancer (GC). Decreased SFTA1P suppresses tumor growth and may serve as a diagnostic and therapeutic target for GC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pseudogenes were historically considered non-functional.
  • Emerging evidence highlights pseudogene-derived long non-coding RNAs (lncRNAs) as critical regulators in human cancers, including gastric cancer (GC).

Purpose of the Study:

  • To investigate the role of the pseudogene-derived lncRNA SFTA1P in gastric cancer (GC).
  • To explore SFTA1P as a potential diagnostic and therapeutic target for GC.

Main Methods:

  • Quantitative real-time PCR to assess SFTA1P expression levels in GC tissues and adjacent normal tissues.
  • Correlation analysis between SFTA1P expression and clinical parameters (TNM stage, tumor size, metastasis, prognosis).
  • Gain-of-function experiments (overexpression) to evaluate the functional impact of SFTA1P on GC cell behavior (proliferation, migration, invasion).
  • Investigation of the potential molecular mechanism involving TP53.

Main Results:

  • SFTA1P was significantly down-regulated in GC tissues compared to normal tissues.
  • Lower SFTA1P expression correlated with advanced TNM stage, larger tumor size, lymphatic metastasis, and poorer patient prognosis.
  • Overexpression of SFTA1P inhibited GC cell proliferation, migration, and invasion.
  • Down-regulation of SFTA1P was associated with decreased TP53 expression.

Conclusions:

  • The pseudogene-derived lncRNA SFTA1P acts as a tumor suppressor in gastric cancer.
  • SFTA1P represents a potential diagnostic biomarker and therapeutic target for GC.
Keywords:
SFTA1Pgastric cancerlncRNApseudogene

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