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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

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Related Experiment Video

Updated: Feb 13, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Multifactorial non-cirrhotic hyperammonaemic encephalopathy.

Katherine Elizabeth Triplett¹, Ronan Murray^2,3, Matthew Anstey^1,4

¹Intensive Care, Sir Charles Gairdner Hospital, Nedlands, Australia.

BMJ Case Reports

|March 11, 2018

Summary

A patient with bipolar disorder developed acute confusion due to high ammonia levels. This was caused by a urinary tract infection with Klebsiella pneumoniae and valproate medication, leading to hyperammonaemic encephalopathy.

Area of Science:

Neurology
Infectious Diseases
Pharmacology

Background:

Keywords:

adult intensive care neurology unwanted effects / adverse reactions urinary tract infections

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Hyperammonaemic encephalopathy is a serious condition characterized by elevated ammonia levels in the blood, leading to neurological dysfunction.
Non-cirrhotic hyperammonaemic encephalopathy can arise from various factors, including infections and medication side effects.
Valproate is a commonly prescribed anticonvulsant and mood stabilizer with known potential to cause hyperammonaemia.