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Related Experiment Video

Updated: Feb 13, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Prospective associations between white matter hyperintensities and lower extremity function.

So Young Moon1, Philipe de Souto Barreto2, Yves Rolland2

  • 1From Gerontopole of Toulouse (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.) and Department of Epidemiology and Public Health (S.A.), University Hospital of Toulouse (CHU-Toulouse); UMR INSERM 1027 (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.), University of Toulouse III, France; Department of Neurology (S.Y.M.), Ajou University School of Medicine, Kyungki-do, Republic of Korea; UPMC Univ Paris 06 (M.C.), UMR S 1127, ICM, Sorbonne Universités; Inserm (M.C.), U1127; CNRS (M.C.), UMR 7225; ICM (M.C.); Inria Paris-Rocquencourt (M.C.), Paris; UNATI (J.F.M.), Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette; and CATI Multicenter Neuroimaging Platform (A.B., L.F., J.F.M., M.C.), cati-neuroimaging.com, France. symoon.bv@gmail.com.

Neurology
|March 11, 2018
PubMed
Summary
This summary is machine-generated.

White matter hyperintensities (WMH) and their progression are linked to declining lower extremity function in older adults. Faster WMH progression significantly impacts physical performance over time.

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Area of Science:

  • Neuroimaging
  • Gerontology
  • Neurology

Background:

  • White matter hyperintensities (WMH) are common in older adults.
  • The relationship between WMH and lower extremity function (LEF) requires further investigation.

Purpose of the Study:

  • To evaluate the association between white matter hyperintensities (WMH) and the decline in lower extremity function (LEF) over three years in older adults with memory complaints.

Main Methods:

  • Brain MRI data from 458 older adults (≥70 years) were analyzed.
  • Lower extremity function was assessed using the Short Physical Performance Battery (SPPB).
  • Mixed-effect linear regressions modeled the relationship between baseline WMH, WMH progression, and SPPB scores over time.

Main Results:

  • Both baseline WMH volume and WMH progression were significantly associated with a decline in SPPB performance.
  • Higher baseline WMH volume and faster WMH progression correlated with poorer LEF.
  • Clinically meaningful differences in SPPB scores were observed between fast and slow WMH progression groups.

Conclusions:

  • Baseline WMH and its progression are associated with longitudinal decline in lower extremity function in older adults.
  • The speed of WMH progression is a critical factor influencing LEF during aging.
  • These findings highlight the importance of monitoring WMH progression for maintaining physical function in older populations.