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Updated: Feb 13, 2026

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Idelalisib and Rituximab in 17p Deletion-Positive Splenic Marginal Zone Lymphoma

Aby Z Philip1

  • 1From the Hematology & Oncology Department, Essentia Health Cancer Center, Duluth, Minnesota.

Journal of the National Comprehensive Cancer Network : JNCCN
|March 11, 2018
PubMed

Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell malignancy involving the spleen and bone marrow. Various cytogenetic abnormalities with prognostic value have been identified in SMZL. Complexity of karyotype, 14q aberrations, and TP53 deletions have been found to be poor prognostic indicators. We report an unusual case of SMZL with a complex karyotype including 17p deletion, primarily refractory to 2 chemoimmunotherapy regimens, that responded well to treatment with phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitors idelalisib and rituximab.

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