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The dose-response analysis between BMI and common chronic diseases in northeast China

Jianxing Yu1, Yuchun Tao1, Jing Dou1

  • 1Epidemiology and Biostatistics, School of Public Health, No. 1163 Xinmin Street, Jilin University, Changchun, Jilin, 130021, China.

Scientific Reports
|March 11, 2018
PubMed

Insights

High body mass index (BMI) significantly increases the risk of chronic diseases like hypertension and dyslipidemia, particularly in middle-aged men. This risk escalates with age and is amplified by smoking and drinking habits.

Area of Science:

  • Public Health
  • Epidemiology
  • Chronic Disease Research

Background:

  • High body mass index (BMI) is a known risk factor for chronic diseases.
  • Previous studies lacked detailed dose-response analyses between BMI and chronic conditions.

Purpose of the Study:

  • To investigate the dose-response relationship between BMI and chronic diseases (hypertension, dyslipidemia, metabolic syndrome) in Northeast China.
  • To analyze age- and gender-specific trends in BMI and associated chronic disease risks.

Main Methods:

  • Utilized data from 16,412 participants aged 18-79 in Jilin province, China (2012).
  • Employed the lambda-mu-sigma (LMS) method for BMI trends and restricted cubic splines for non-linear dose-response analyses.
  • Examined the influence of smoking and drinking habits on BMI-related disease risks.

Main Results:

  • BMI trends varied by age and gender, with rapid increases in youth, stability in middle age, and slow decline in old age.
  • Odds ratios for chronic diseases increased significantly with BMI, especially in middle-aged and older adults, particularly men.
  • Smokers and drinkers exhibited higher BMI-related risks for chronic diseases.

Conclusions:

  • BMI has a significant dose-response relationship with hypertension, dyslipidemia, and metabolic syndrome.
  • The risk associated with high BMI escalates dramatically in middle age and old age, especially for men.
  • Lifestyle factors like smoking and drinking exacerbate the risk of chronic diseases linked to high BMI.

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