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Updated: Feb 13, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

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Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease

Clarissa S Craft1, Thomas J Broekelmann2, Robert P Mecham2

  • 1Division of Bone and Mineral Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States.

Matrix Biology : Journal of the International Society for Matrix Biology
|March 11, 2018
PubMed

Insights

Microfibril-associated glycoproteins 1 and 2 (MAGP-1, MAGP-2) are vital extracellular matrix proteins influencing microfibril function. Their dysfunction is linked to human diseases, including aneurysms, metabolic disorders, and cancer.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Microfibril-associated glycoproteins 1 and 2 (MAGP-1, MAGP-2) are key components of extracellular matrix microfibrils.
  • These proteins interact with fibrillin, influencing microfibril structure and function in vertebrates.

Purpose of the Study:

  • To review the current understanding of MAGP-1 and MAGP-2 functions.
  • To explore the relationship between MAGPs and human diseases.

Main Methods:

  • Literature review of studies on MAGP-1 and MAGP-2.
  • Analysis of genetic mutations and their associated phenotypes.
  • Examination of MAGP-2 as a cancer biomarker.

Main Results:

  • MAGPs bind TGFβ and BMPs, modulating Notch signaling.
  • Mutations in MAGP-1/MAGP-2 are associated with thoracic aneurysms and metabolic diseases.
  • MAGP-2 is a potential biomarker in human cancers.
  • MAGP-1/MAGP-2 deficient mice exhibit multi-organ system defects.

Conclusions:

  • MAGPs play critical roles in diverse biological processes.
  • Dysregulation of MAGPs contributes to various human pathologies.
  • Further research into MAGPs may yield new therapeutic strategies and diagnostic tools.
Keywords:
AneurysmsBoneCancerFibrillinMAGPMicrofibrilMicrofibril-associated glycoproteinObesity

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