Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

3.5K
3.5K
Organization of Genes02:07

Organization of Genes

73.7K
Overview
73.7K
Cellular Differentiation00:57

Cellular Differentiation

5.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.6K
Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T<sub>FH</sub> cell programs by pathogen and species.

Nature immunology·2025
Same author

Discovering effector domains in human transcription factors.

Trends in immunology·2023
Same author

Tipping the balance in CD4<sup>+</sup> T cells.

Nature immunology·2023
Same author

One degree of separation: urgent questions surrounding new USA laws in women's healthcare.

Trends in immunology·2022
Same author

Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans.

Cell reports·2022
Same author

Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis.

Trends in immunology·2021

Related Experiment Video

Updated: Feb 13, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.5K

Metabolites, genome organization, and cellular differentiation gene programs.

Danielle A Chisolm1, Amy S Weinmann1

  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Current Opinion in Immunology
|March 12, 2018
PubMed
Summary

Metabolism influences cellular differentiation by regulating genome organization and epigenetic processes. Nutrients like glutamine impact metabolites such as alpha-ketoglutarate, affecting gene interpretation and cell fate decisions.

More Related Videos

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.6K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.9K

Related Experiment Videos

Last Updated: Feb 13, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.5K
Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.6K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.9K

Area of Science:

  • Cellular Biology
  • Metabolomics
  • Epigenetics

Background:

  • Metabolism dynamically regulates cellular differentiation.
  • Metabolites bridge nutrient status and genome interpretation.
  • Metabolites influence epigenetic modifications and genome organization.

Purpose of the Study:

  • Review recent research on metabolism's role in genome organization and interpretation.
  • Elucidate how metabolism influences cellular differentiation decisions.
  • Discuss similarities and differences in differentiation states.

Main Methods:

  • Literature review of recent research.
  • Integration of findings on nutrient-metabolite-epigenetic pathways.
  • Comparative analysis of differentiation mechanisms.

Main Results:

  • Metabolism, via metabolites like alpha-ketoglutarate (regulated by glutamine), impacts epigenetic states.
  • Metabolic pathways influence CTCF binding and genome organization.
  • Mechanisms are conserved but distinct in embryonic stem (ES) cells and T cells.

Conclusions:

  • Metabolism is crucial for genome organization and interpretation, guiding cellular differentiation.
  • Understanding these pathways offers insights into normal and dysregulated cellular states, including cancer immunology.