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Genome-wide QTL analysis for anxiety trait in bipolar disorder type I
J Contreras1, E Hare2, G Chavarría-Soley3
1Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, Costa Rica.
Journal of Affective Disorders
|March 12, 2018
Summary
Genetic linkage analysis suggests a region on chromosome 2 (2q13-q14) may contain genes contributing to anxiety trait in bipolar disorder type I (BPI). Further research is needed to confirm these findings.
Area of Science:
- Psychiatric Genetics
- Neuroscience
- Human Genetics
Background:
- Bipolar disorder type I (BPI) exhibits strong familial aggregation, indicating a significant genetic influence.
- Anxiety trait has been previously identified as a potential endophenotype for BPI.
Purpose of the Study:
- To identify quantitative trait loci (QTLs) associated with anxiety trait in individuals with BPI.
- To perform a multipoint quantitative trait linkage analysis in a Costa Rican population sample.
Main Methods:
- Utilized the Quantitative Trait Loci (QTL) method with variance-components models.
- Employed Sequential Oligogenic Linkage Analysis Routines (SOLAR) software.
- Analyzed data from 619 individuals using 5606 single nucleotide polymorphisms (SNPs).
Main Results:
- A suggestive linkage signal was detected on chromosome 2 (2q13-q14) with a LOD score of 2.01.
- This finding indicates a potential genetic locus influencing anxiety trait in BPI.
Conclusions:
- The chromosomal region 2q13-q14 may harbor candidate genes crucial for the pathophysiology of BPI and anxiety.
- These results are preliminary and require further investigation, considering potential confounding factors were not assessed.
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