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Respiratory syncytial virus bronchiolitis and hypertransaminasemia

Salvatore Giordano1, Maria Di Gangi1, Maria Concetta Failla1

  • 1U.O. di Malattie Infettive Pediatriche, Ospedale G. Di Cristina - ARNAS Civico - Palermo, Italy.

Le Infezioni in Medicina
|March 12, 2018
PubMed

Insights

Respiratory syncytial virus (RSV) bronchiolitis, a common childhood illness, can rarely cause temporary liver issues. This study highlights three cases of RSV bronchiolitis in children with elevated transaminase levels.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Bronchiolitis is a frequent lower respiratory tract infection in infants, primarily caused by respiratory syncytial virus (RSV).
  • RSV infections are typically characterized by respiratory symptoms but can present with extra-pulmonary manifestations.
  • Elevated transaminase levels, indicative of liver injury, are rarely reported in conjunction with RSV infections.

Observation:

  • This paper details three pediatric cases of bronchiolitis attributed to RSV.
  • All three children presented with clinically diagnosed RSV bronchiolitis.
  • Each case exhibited transiently elevated serum transaminase levels.

Findings:

  • The findings suggest a potential link between RSV bronchiolitis and temporary liver enzyme elevation in children.
  • The observed transaminase elevations were transitory, resolving without specific intervention for the liver condition.
  • This case series expands the understanding of RSV's potential extra-pulmonary effects.

Implications:

  • Clinicians should consider monitoring liver function in children with severe RSV bronchiolitis.
  • Further research is warranted to elucidate the mechanism of RSV-induced liver injury.
  • Recognizing these extra-pulmonary manifestations can aid in comprehensive patient management.

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