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Related Experiment Videos

Platelets as effectors in immune and hypersensitivity reactions.

A Capron, M Joseph, J C Ameisen

    International Archives of Allergy and Applied Immunology
    |January 1, 1987
    PubMed
    Summary

    Platelets possess IgE receptors, mediating immune responses in parasitic infections and allergic reactions. T cell factors regulate platelet activation, offering new insights into hypersensitivity disorders.

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    Area of Science:

    • Immunology
    • Hematology
    • Allergology

    Background:

    • Human blood platelets express IgE receptors (Fc epsilon R2) with specific binding properties.
    • These receptors are involved in IgE-dependent platelet activation and effector functions.

    Purpose of the Study:

    • To characterize IgE receptors on human platelets.
    • To investigate the role of platelets in parasitic infections and allergic disorders.
    • To explore the regulation of platelet functions by T cell factors.

    Main Methods:

    • Characterization of IgE receptors using anti-Fc epsilon R2 monoclonal antibody.
    • Demonstration of IgE-dependent platelet killing in parasitic infections.
    • Assessment of platelet activation by allergens and NSAIDs in allergic patients.

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  • Identification of T cell factors (PASL, IFN-gamma) regulating platelet functions.

    • Main Results:

    • Platelets have 600-1,000 IgE binding sites per cell (Ka = 3 X 10(7) M-1).
    • IgE-dependent platelet activation observed in schistosomiasis, filariasis, allergic asthma, and Hymenoptera venom sensitivity.
    • Aspirin-sensitive asthma involves non-IgE-dependent platelet activation.
    • T cell-derived factors differentially regulate platelet activation and killing.

    Conclusions:

    • Platelets play a significant role in immune and hypersensitivity reactions.
    • IgE receptors on platelets are crucial in allergic and pseudoallergic disorders.
    • T cell factors offer novel perspectives for diagnosing and preventing these conditions.