Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

6.7K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.7K
Cell Migration01:09

Cell Migration

18.9K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.9K
Machines01:19

Machines

581
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
581
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

5.7K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
5.7K
Power01:08

Power

13.1K
The concept of work involves force and displacement; meanwhile, the work-energy theorem relates the net work done on a body to the difference in its kinetic energy, calculated between two points on its trajectory. While none of these quantities or relations involves time explicitly, we know that the time available to accomplish work is often just as important as the amount of work itself. For example, sprinters in a race may have achieved the same velocity at the finish, therefore,...
13.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular insights into profilin 1-dependent regulation of cellular phosphatidylinositol (4,5)-bisphosphate.

Journal of cell science·2026
Same author

Neutrophil serine proteases degrade endothelial cortactin and promote extravasation.

The Journal of cell biology·2026
Same author

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate.

bioRxiv : the preprint server for biology·2026
Same author

Exploring the Substitution of the C21-OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates.

Chembiochem : a European journal of chemical biology·2025
Same author

Differential interference with actin-binding protein function by acute cytochalasin B.

Current biology : CB·2025
Same author

Correction: Lambert et al. Cytochalasans and Their Impact on Actin Filament Remodeling. <i>Biomolecules</i> 2023, <i>13</i>, 1247.

Biomolecules·2025

Related Experiment Video

Updated: Feb 13, 2026

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy
09:10

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy

Published on: May 12, 2015

9.8K

Imaging the Molecular Machines That Power Cell Migration.

Anika Steffen1, Frieda Kage1,2, Klemens Rottner3,4

  • 1Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|March 12, 2018
PubMed
Summary

Animal cell migration relies on the actin cytoskeleton to drive cell surface dynamics and protrusions. Imaging molecular components reveals how these structures function in cell movement.

Keywords:
ActinFMNLFluorescence imagingLive cell imagingMigrationVASPWAVE complex

More Related Videos

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

12.2K
Molecular Imaging to Target Transplanted Muscle Progenitor Cells
09:24

Molecular Imaging to Target Transplanted Muscle Progenitor Cells

Published on: March 27, 2013

9.4K

Related Experiment Videos

Last Updated: Feb 13, 2026

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy
09:10

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy

Published on: May 12, 2015

9.8K
Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

12.2K
Molecular Imaging to Target Transplanted Muscle Progenitor Cells
09:24

Molecular Imaging to Target Transplanted Muscle Progenitor Cells

Published on: March 27, 2013

9.4K

Area of Science:

  • Cell Biology
  • Biophysics
  • Molecular Imaging

Background:

  • Animal cell migration is crucial for development and disease.
  • The actin cytoskeleton powers cell surface dynamics and protrusions.
  • Understanding molecular mechanisms driving migration is essential.

Purpose of the Study:

  • To illustrate imaging techniques for actin-driven cell migration.
  • To showcase the diversity of molecular components in cell protrusions.
  • To connect molecular distribution and dynamics to cell migration function.

Main Methods:

  • Imaging of molecular constituents involved in actin polymerization.
  • Visualization of actin filament bundles and networks.
  • Analysis of dynamic changes in cell protrusion morphology.

Main Results:

  • Demonstrated diverse subcellular distributions of functional molecular components.
  • Illustrated complex dynamic changes in protrusion size, shape, and orientation in 3D.
  • Provided examples of imaging actin-driven processes.

Conclusions:

  • Imaging reveals the functional roles of molecular machines in cell migration.
  • Dynamic changes in cell protrusions are linked to biochemical functions.
  • Understanding these dynamics is key to deciphering cell migration mechanisms.