Related Experiment Video
Updated: Feb 13, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
34.2K
Indication, Patient Selection, and Referral Pathways for Left Atrial Appendage Closure
Tawseef Dar1, Mohit K Turagam2, Bharath Yarlagadda1
1Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Hospital and Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Interventional Cardiology Clinics
|March 13, 2018
Summary
Left atrial appendage closure (LAAC) offers stroke prevention for patients unsuitable for anticoagulation. Optimal patient selection and post-procedure care require further research.
Area of Science:
- Cardiology
- Medical Devices
- Stroke Prevention
Background:
- Left atrial appendage closure (LAAC) is a key strategy for stroke prevention.
- It is particularly relevant for patients intolerant of oral anticoagulation.
- Effective patient selection for LAAC remains a significant clinical challenge.
Purpose of the Study:
- To outline the clinical characteristics and indications for LAAC.
- To propose a referral system for identifying suitable LAAC candidates.
- To highlight areas needing further investigation in LAAC therapy.
Main Methods:
- Review of clinical characteristics and indications for LAAC.
- Description of a proposed referral system for patient selection.
- Identification of knowledge gaps and future research directions.
Main Results:
- LAAC is a viable stroke prevention alternative.
- Patient selection presents a paradox between trial data and real-world application.
- Further studies are needed for device comparison and optimal antithrombotic strategies.
Conclusions:
- LAAC is an important option for stroke prevention in specific patient groups.
- Refining patient selection criteria is crucial for maximizing LAAC benefits.
- Further research is essential to optimize LAAC device comparisons and post-procedure antithrombotic regimens.
Related Concept Videos
02:39Indicators
61.1K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
61.1K
01:23Surface Appendages of Archaea
691
Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...
691
01:27C4 Pathway and CAM
49.3K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
01:28Angle Closure Glaucoma: Treatment
1.3K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
01:32What is Natural Selection?
129.8K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.8K
01:29Mechanical Ventilation I: Indication and Settings
2.9K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.9K