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Updated: Feb 13, 2026
05:16
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
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Hyperuricaemia as a prognostic factor for acute ischaemic stroke
F H Cabrera Naranjo1, P Saavedra Santana2, A González Hernández3
1Servicio de Neurología, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, España.
Neurologia
|March 13, 2018
Summary
Serum uric acid levels in acute ischemic stroke patients show a nonlinear association with functional outcomes. Both very low and very high uric acid concentrations correlate with poorer stroke prognosis, suggesting a dual role.
Area of Science:
- Neurology
- Biochemistry
- Clinical Medicine
Background:
- Conflicting results exist regarding uric acid's role as an acute stroke prognostic biomarker.
- Uric acid's complex relationship with stroke outcomes requires further investigation.
Purpose of the Study:
- To investigate the association between serum uric acid levels and functional prognosis in acute ischemic stroke patients.
- To clarify the nonlinear relationship between uric acid and stroke outcomes.
Main Methods:
- Blood samples were analyzed from 600 acute ischemic stroke patients.
- Functional prognosis was assessed using the modified Rankin Scale (mRS).
- Patients receiving reperfusion therapy were excluded to avoid confounding factors.
Main Results:
- A nonlinear relationship was observed between serum uric acid levels and functional prognosis at discharge.
- 73% of patients achieved good functional outcomes (mRS ≤2).
- Both very low and very high uric acid levels were associated with poorer prognosis.
Conclusions:
- Serum uric acid levels are significantly associated with functional prognosis in acute ischemic stroke.
- The nonlinear association suggests a dual role for uric acid: a potential risk factor and a neuroprotective agent due to its antioxidant properties.
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