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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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[Induced drug uveitis and drug side effects in ophthalmology]

S Trad1, C Bonnet2, D Monnet3

  • 1Service de médecine interne, hôpital Ambroise-Paré, 92104 Boulogne-Billancourt, France.

La Revue De Medecine Interne
|March 13, 2018
PubMed

Insights

Ocular drug side effects can impact eye structures. This review aids clinicians in recognizing drug-induced ocular toxicity and inflammation, particularly from anti-TNF and targeted cancer therapies.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Oncology

Background:

  • Ocular drug side effects present diverse clinical manifestations.
  • Early identification of drug-induced ocular toxicity is crucial to prevent irreversible damage.

Purpose of the Study:

  • To assist clinicians in diagnosing unexplained ocular injuries as drug-induced.
  • To recognize paradoxical ocular inflammation in patients on anti-tumor necrosis factor (anti-TNF) therapy.
  • To enhance understanding of ocular toxicities associated with targeted cancer therapies, including tyrosine kinase inhibitors.

Main Methods:

  • Literature review of ocular drug toxicities.
  • Analysis of clinical presentations of drug-induced ocular inflammation.
  • Review of emerging toxicities from novel cancer therapeutics.

Main Results:

  • Drug-induced ocular toxicity can mimic various eye conditions.
  • Anti-TNF therapy may lead to paradoxical ocular inflammation.
  • Tyrosine kinase inhibitors are associated with specific ocular side effects.

Conclusions:

  • Clinicians should consider drug-induced toxicity in unexplained ocular injuries.
  • Awareness of drug-induced ocular inflammation is vital, especially in patients on anti-TNF agents.
  • Knowledge of targeted cancer therapy ocular toxicities is essential for patient management.
Keywords:
Anti-TNFCorneaCornéeDrug-inducedEffets secondairesIatrogénieInhibiteurs des tyrosines kinasesKerathopathyKeratitisKératiteKératopathiesNévrite optiqueOcularOptic neuritisRetinopathyRétinopathieSide effectsToxicityToxicité oculaireTyrosine kinase inhibitorsUveitisUvéites

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