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A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
Published on: May 20, 2016
[Specific aspects of the management of women with epilepsy]
1Epilepsy Unit, hôpital de la Pitié-Salpêtrière, AP-HP, 47, boulevard de l'Hôpital, 75013 Paris, France; Rehabilitation Unit, hôpital de la Pitié-Salpêtrière, AP-HP, 47, boulevard de l'Hôpital, 75013 Paris, France; Centre de recherche de l'institut du cerveau et de la moëlle épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 Inserm, 47, boulevard de l'Hôpital, 75013 Paris, France; Sorbonne université, Paris 6, France.
Abstract:
Catamenial epilepsy, defined as the exacerbation of the frequency of seizures in a given phase of the menstrual cycle, affects 35% of women. In women with catamenial epilepsy with perimenstrual seizures, progesterone therapy may be effective. In case of enzyme inducer AEDs, hormonal contraception is deprecated (estroprogestative or progestative pill, progestative implant, patches or hormonal rings). Because of its high malformative teratogenic potential, its possible depressive cognitive effects and the autistic risk, sodium valproate is not indicated during pregnancy. To date, the most recommended AEDs for pregnancy are lamotrigine and levetiracetam. Plasma drug monitoring is recommended during pregnancy. The decision to breastfeed remains individual depending mainly on the term of delivery and the type of antiepileptic treatment.
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