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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
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Dual-responsive drug delivery systems prepared by blend electrospinning
Heyu Li1, Qingqing Sang1, Junzi Wu1
1College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
International Journal of Pharmaceutics
|March 13, 2018
Summary
This study developed dual-responsive drug delivery fibers using poly(N-isopropylacrylamide) and Eudragit® L100-55. These biocompatible fibers show tunable ketoprofen release based on temperature and pH, advancing smart drug delivery systems.
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Developing advanced drug delivery systems is crucial for targeted and controlled medication release.
- Stimuli-responsive polymers offer potential for sophisticated drug delivery platforms.
- Poly(N-isopropylacrylamide) (PNIPAAm) and Eudragit® L100-55 (EL100-55) are known for their thermosensitive and pH-sensitive properties, respectively.
Purpose of the Study:
- To synthesize and characterize dual-responsive drug delivery fibers.
- To investigate the incorporation and release of ketoprofen (KET) from composite fibers.
- To evaluate the biocompatibility of the developed materials.
Main Methods:
- Free-radical polymerization for PNIPAAm synthesis.
- Co-dissolution of PNIPAAm and EL100-55 followed by electrospinning.
- Incorporation of ketoprofen (KET) into the polymer matrix.
- Characterization using X-ray diffraction and FTIR spectroscopy.
- In vitro drug release studies at varying pH and temperatures.
- MTT assay for biocompatibility assessment.
Main Results:
- Smooth, cylindrical composite fibers were successfully fabricated without phase separation.
- Ketoprofen was confirmed to be in an amorphous state within the fiber matrix.
- Drug release demonstrated significant dependence on both temperature and pH, confirming dual responsiveness.
- PNIPAAm/EL100-55 composite fibers exhibited excellent biocompatibility with L929 fibroblasts (>80% viability).
Conclusions:
- The study successfully created dual-responsive PNIPAAm/EL100-55 composite fibers for drug delivery.
- The fibers effectively encapsulate and release ketoprofen in a stimuli-dependent manner.
- These materials hold promise for developing multi-responsive drug delivery and tissue engineering applications.
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