Modulation-demodulation hypothesis of periodic breathing in human respiration

Periodic breathing (PB) is a diseased condition of the cardiorespiratory system, and mathematically it is modelled as an oscillation. Modeling approaches replicate periodic oscillation in the minute ventilation due to a higher than normal gain of the feedback signals from the chemoreceptors coupled with a longer than normal latency in feedback, and do not consider the waxing-waning pattern of the oronasal airflow. In this work, a noted regulation model is extended by integrating respiratory mechanics and respiratory central pattern generator (rCPG) model, using modulation-demodulation¹ hypothesis. This is a top-down modeling approach, and it is assumed that the sensory feedback signal from the chemoreceptors modulates the output of the rCPG model. It is also assumed that the brainstem network is responsible for the demodulation process. The respiratory mechanics is modeled as a multi-input multi-output (MIMO) system, where modulated and demodulated neural signals are applied as input and the minute ventilation and the oronasal airflow are specified as output. The minute ventilation signal drives the regulation model, completing the feedback loop. The proposed model is validated by comparing the model output with the clinical data. Using the modulation-demodulation hypothesis, a respiratory mechanics model is formulated in the form of a linear state-space model, which can be useful for providing assisted ventilation in clinical conditions.