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Developmental changes in the rat atriopeptin hormonal system.

Y F Wei, C P Rodi, M L Day

    The Journal of Clinical Investigation
    |May 1, 1987
    PubMed
    Summary
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    Fetal atriopeptin (AP) hormonal system is functional, with high fetal plasma levels potentially from maternal transfer and influenced by renal capacity. The fetus responds to stimuli, releasing AP, indicating a mature-like response to intracardiac pressure.

    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology
    • Neonatal Research

    Background:

    • Atriopeptin (AP) plays a crucial role in cardiovascular homeostasis.
    • Understanding AP's role during fetal development is essential for neonatal health.
    • Limited data exists on fetal AP synthesis, storage, and release mechanisms.

    Purpose of the Study:

    • To investigate fetal atriopeptin (AP) synthesis, storage, and release.
    • To compare fetal and maternal AP levels and their regulation.
    • To determine the functional capacity of the fetal AP system.

    Main Methods:

    • Measurement of plasma atriopeptin immunoreactivity (APir) and NH2-terminal fragment immunoreactivity (NTFir) in fetuses and mothers.
    • Quantification of AP content in fetal and adult cardiac atria and ventricles.

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  • Analysis of AP messenger RNA (mRNA) levels in fetal and postnatal cardiac tissues.
  • Infusion studies with exogenous atriopeptin and administration of vasopressin and indomethacin.

    • Main Results:

    • Fetal plasma APir and NTFir levels were significantly higher than maternal levels.
    • Ventricular AP content was high in fetuses and decreased postnatally, while atrial content increased.
    • Fetal cardiac AP mRNA levels were high in ventricles and low in atria, with a postnatal shift.
    • Exogenous atriopeptin infusion to mothers caused parallel increases in fetal and maternal levels.
    • Fetal plasma AP levels reflected reduced renal metabolic capacity and responded to vasopressin and indomethacin stimuli.

    Conclusions:

    • The atriopeptin hormonal system is functional in the fetus.
    • Fetal AP levels are influenced by maternal transfer and renal function.
    • The fetal cardiovascular system demonstrates a mature-like response to stimuli increasing intracardiac pressure.