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Related Experiment Videos

Visual loss in cryptococcal meningitis.

S Ofner, R S Baker

    Journal of Clinical Neuro-Ophthalmology
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Cryptococcal meningitis can cause vision loss through intracranial hypertension or direct optic nerve invasion. This study found direct fungal invasion in the optic nerve sheath of a living patient, a first demonstration.

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    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Neurology

    Background:

    • Optic neuropathy and visual loss are known complications of elevated intracranial pressure.
    • Cryptococcal meningitis is associated with visual loss, often attributed to intracranial hypertension.
    • However, poor outcomes from optic nerve sheath fenestration suggest direct organismal invasion may also cause visual loss.

    Observation:

    • A patient with severe visual loss due to cryptococcal meningitis was studied.
    • Optic nerve sheath fenestration was performed on the patient.
    • The optic nerve sheath tissue was analyzed for the presence of Cryptococcus organisms.

    Findings:

    • Direct invasion of the optic nerve sheath by Cryptococcus organisms was demonstrated.
    • This finding was observed in tissue obtained from a living patient during fenestration.

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  • This is the first report to show direct fungal invasion in the optic nerve sheath of a living patient.

    • Implications:

    • This finding supports direct organismal invasion as a significant mechanism for visual loss in cryptococcal meningitis.
    • It may influence treatment strategies for ocular complications associated with this infection.
    • Further research is warranted to understand the prevalence and impact of direct invasion versus intracranial hypertension on visual outcomes.