Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual differences in plasma cortisol changes during mania and depression.

P R Joyce, R A Donald, P A Elder

    Journal of Affective Disorders
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preliminary investigation of the effect of treating sheep during pregnancy with a vitamin A, D, E formulation on the incidence of vaginal prolapse.

    New Zealand veterinary journal·2019
    Same author

    A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury.

    Redox report : communications in free radical research·2016
    Same author

    The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function.

    Acta neuropsychiatrica·2016
    Same author

    02-07 The effect of personality disorder on treatment for depression: psychotherapy vs. medication.

    Acta neuropsychiatrica·2016
    Same author

    Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain.

    Acta neuropsychiatrica·2016
    Same author

    No change in neuropsychological dysfunction or emotional processing during treatment of major depression with cognitive-behaviour therapy or schema therapy.

    Psychological medicine·2015
    Same journal

    The longitudinal relationship between co-rumination and depressive symptoms in adolescents: A systematic review and meta-analytic structural equation modeling.

    Journal of affective disorders·2026
    Same journal

    Child-experienced discrimination and parent mental health in Latino families.

    Journal of affective disorders·2026
    Same journal

    Suicide risk prediction and analysis of associated factors among high school students in four provinces of China based on explainable machine learning.

    Journal of affective disorders·2026
    Same journal

    Integrating hypertriglyceridemia, inflammation, and β-cell stress in clozapine- and olanzapine-associated pancreatitis.

    Journal of affective disorders·2026
    Same journal

    Exploring the functioning trajectories and associated factors in adolescents with first-diagnosis major depressive disorder: Evidence from the sBEAD cohort.

    Journal of affective disorders·2026
    Same journal

    Effects of a self-directed cognitive behavioral therapy manual on depressive symptoms among youths incarcerated for drug-related offenses.

    Journal of affective disorders·2026
    See all related articles

    Cortisol levels in rapid cycling bipolar disorder patients increase before and during depression. Mania shows variable cortisol, often decreasing initially, then rising with severity. This study explores cortisol dynamics in mood episodes.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Bipolar Affective Disorder Research

    Background:

    • Bipolar affective disorder (BPAD) is a mood disorder characterized by shifts in mood, energy, and activity levels.
    • Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, particularly cortisol secretion, is frequently observed in BPAD.
    • Rapid cycling BPAD, defined by four or more mood episodes per year, presents unique challenges in understanding HPA axis function.

    Purpose of the Study:

    • To longitudinally investigate daytime plasma cortisol levels in patients with rapid cycling bipolar affective disorder.
    • To assess the relationship between cortisol levels and specific mood states (depression, mania) within individual patients.
    • To explore potential differences in cortisol patterns during the onset and progression of manic and depressive episodes.

    Related Experiment Videos

    Main Methods:

    • Longitudinal measurement of daytime plasma cortisol levels.
    • Assessment of cortisol changes in relation to multiple affective episodes in four rapid cycling BPAD patients.
    • Individualized analysis of mood state and corresponding cortisol levels.

    Main Results:

    • Three out of four patients exhibited elevated cortisol levels during depressive episodes.
    • Increased cortisol levels were also observed in the days preceding depressive episodes.
    • Cortisol levels during manic episodes were variable, with two patients showing lower levels during mania.

    Conclusions:

    • Cortisol levels appear to increase prior to and during depressive episodes in rapid cycling BPAD.
    • The observed variability in cortisol during mania suggests complex HPA axis regulation.
    • It is hypothesized that decreased cortisol in early mania reflects neurochemical changes, while elevated levels may occur in dysphoric or severe mania.