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The Development of Acute Systemic Multiple Thrombosis after Achieving Remission during Systemic Glucocorticoid

Kazuhiro Toyama1,2, Atsushi Yasumoto3, Fumihiko Nakamura2

  • 1Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|March 13, 2018
PubMed

Acquired hemophilia A (AHA) is a hemorrhagic disorder. Whether or not severe thrombotic events can develop without the use of bypassing agents in AHA patients is unclear. An 80-year-old woman with AHA underwent immunosuppressive therapy with prednisolone at 1 mg/kg daily. After achieving remission, she suddenly developed multiple organ failure due to acute systemic thrombosis and died within a few hours of the diagnosis. Patients with AHA, especially those with risk factors for thrombosis, have a considerable risk of developing thrombosis during the recovery phase of factor VIII activity and should be carefully monitored by coagulation testing.

Keywords:
acquired hemophilia Aglucocorticoid therapythrombosisvon Willebrand factor

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