Falcine meningioma in Von Hippel-Lindau disease: An unusual association

Area of Science:

• Neuro-oncology
• Genetics
• Neurosurgery

Background:

• Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder associated with diverse tumor development.
• Supratentorial lesions are uncommon in VHL disease, with falcine meningiomas previously unreported.
• Accurate diagnosis often necessitates histopathological examination due to challenging differential diagnoses.

Observation:

• A patient with VHL disease developed a falcine meningioma 2 years post-surgery for a cerebellar hemangioblastoma.
• Magnetic resonance imaging (MRI) revealed an iperintense solid mass at the posterior falx.
• Histological analysis confirmed the mass as a meningioma.

Findings:

• This report presents the unique case of a falcine meningioma in a patient diagnosed with Von Hippel-Lindau disease.
• The meningioma was incidentally discovered during routine radiological follow-up.
• This represents the first documented instance of a falcine meningioma associated with VHL disease in medical literature.

Implications:

• Highlights the importance of vigilant radiological surveillance in VHL patients, even for rare tumor locations.
• Suggests that meningiomas, though rare, should be considered in the differential diagnosis of supratentorial lesions in VHL patients.
• Proposes surgical management strategies for this rare presentation, contributing to VHL disease management guidelines.