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On the relationship status for Arf and NPM1 - it's complicated
Diana M Mitrea1, Richard W Kriwacki1,2
1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
The FEBS Journal
|March 13, 2018
Abstract:
Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 - a regulator of ribosome biogenesis, and Mdm2 - a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle.