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NanoTRAIL-Oncology: A Strategic Approach in Cancer Research and Therapy

Yesi Shi1, Xin Pang1, Junqing Wang1,2

  • 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.

Advanced Healthcare Materials
|March 13, 2018
PubMed

Insights

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promise for cancer therapy. Nanobiotechnology enhances TRAIL delivery, overcoming limitations for improved anticancer treatments.

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cancer Biology

Background:

  • TRAIL induces apoptosis in cancer cells but faces challenges like limited exposure and drug resistance.
  • Clinical application of TRAIL is hindered by these significant obstacles.
  • Nanobiotechnology offers novel solutions for enhanced drug delivery in cancer therapy.

Purpose of the Study:

  • To review the mechanisms and biological functions of TRAIL.
  • To discuss the current status of TRAIL-based cancer treatments.
  • To explore the application of nanotechnology with TRAIL for advanced cancer therapy.

Main Methods:

  • Review of existing literature on TRAIL and nanobiotechnology.
  • Analysis of strategies for TRAIL delivery, including fusion proteins, membrane engineering, and nanocarriers.
  • Discussion of nanoparticle-based TRAIL (nanoTRAIL) applications.

Main Results:

  • Nanobiotechnology enables improved expression, targeting, and delivery of TRAIL.
  • Functional nanotechnology combined with TRAIL shows potential for enhanced anticancer therapy.
  • nanoTRAIL presents opportunities for efficient and safe bioapplications.

Conclusions:

  • Nanotechnology significantly advances TRAIL-based cancer treatment strategies.
  • nanoTRAIL offers a promising platform for overcoming TRAIL's clinical limitations.
  • Further research in functional nanotechnology is crucial for optimizing nanoTRAIL therapies.
Keywords:
TRAILcancer therapynanoTRAILnanotechnology

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