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Serial Changes in Mannose-Binding Lectin in Patients with Sepsis
Jin Won Huh1, Kyuyoung Song2, Hwa Jung Kim3
1Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Tuberculosis and Respiratory Diseases
|March 13, 2018
Summary
Rising mannose-binding lectin (MBL) levels in septic shock patients correlate with improved survival. This increase also associates with reduced pro-inflammatory and anti-inflammatory cytokine levels, suggesting a favorable prognosis.
Area of Science:
- Immunology
- Critical Care Medicine
- Clinical Biochemistry
Background:
- Mannose-binding lectin (MBL) deficiency increases infection susceptibility.
- Septic shock prognosis is often linked to immune response markers.
- Understanding MBL dynamics in sepsis is crucial for patient outcomes.
Purpose of the Study:
- To investigate serial changes in MBL levels in septic shock patients.
- To correlate MBL level dynamics with 28-day survival prognosis.
- To examine the relationship between MBL levels and key cytokine profiles.
Main Methods:
- 131 septic shock patients were enrolled, with serum MBL and cytokine levels analyzed at baseline and day 7.
- Patients were categorized into four groups based on MBL levels (<1.3 μg/mL or ≥1.3 μg/mL) on days 1 and 7.
- Serum samples from 73 patients were available for day 7 analysis.
Main Results:
- Patients with low MBL on day 1 and high MBL on day 7 demonstrated a favorable 28-day survival prognosis (OR, 1.96).
- A significant decrease in pro-inflammatory cytokines (MCP-1, IL-1β, IL-6, IL-8, IFN-γ) was observed in the high MBL group on day 7.
- Reduced levels of granulocyte-macrophage colony-stimulating factor were also noted in the high MBL group on day 7.
Conclusions:
- An increase in MBL levels during septic shock may indicate a favorable prognosis.
- Rising MBL levels appear to attenuate both pro-inflammatory and anti-inflammatory responses.
- MBL dynamics serve as a potential biomarker for septic shock outcomes.
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