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Updated: Feb 13, 2026

Intra-lymph Node Injection of Biodegradable Polymer Particles
Published on: January 2, 2014
Biodegradable Polymer with Hydrolysis-Induced Zwitterions for Antibiofouling
Qingyi Xie1, Qianni Xie1, Jiansen Pan1
1Faculty of Materials Science and Engineering , South China University of Technology , Guangzhou 510640 , P. R. China.
Abstract:
Persistent protein resistance is critical for marine antibiofouling. We have prepared copolymer of 2-methylene-1,3-dioxepane (MDO), tertiary carboxybetaine ester (TCB), and 7-methacryloyloxy-4-methylcoumarin (MAMC) via radical ring-opening polymerization, where MDO, TCB, and MAMC make the polymer degradable, protein resistible, and photo-cross-linkable, respectively. Our study shows that the polymer can well adhere to the substrate with controlled degradation and water adsorption rate in artificial seawater (ASW). Particularly, the polymer film can generate zwitterions via surface hydrolysis in ASW. Quartz crystal microbalance with dissipation measurements reveal that such hydrolysis-induced zwitterionic surface can effectively resist nonspecific protein adsorption. Moreover, the surface can inhibit the adhesion of marine bacteria Pseudomonas sp. and Vibrio alginolyticus as well as clinical bacterium Escherichia coli.
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