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Circadian leptin concentration changes in critically ill heart failure patients
1Department of Anaesthesiology and Intensive Care, St. Anne's University Hospital, Brno, Czech Republic. Ivan.Cundrle@seznam.cz.
Physiological Research
|March 13, 2018
Summary
Critically ill heart failure patients initially show preserved circadian leptin changes. However, this pattern is lost by the third day, indicating disrupted daily leptin rhythms in critical illness.
Area of Science:
- Endocrinology
- Critical Care Medicine
- Circadian Biology
Background:
- Leptin concentration is physiologically regulated by circadian rhythm.
- Circadian rhythm disruption is common in critically ill patients.
- The preservation of circadian leptin changes in critical illness is unknown.
Purpose of the Study:
- To investigate if circadian leptin concentration changes are preserved in critically ill heart failure patients.
- To compare leptin rhythmicity on the first and third day of critical illness.
Main Methods:
- Studied 10 critically ill heart failure patients requiring mechanical ventilation and sedation.
- Measured plasma leptin concentration every 4 hours over 24 hours on day 1 and day 3 post-admission.
- Analyzed leptin concentration changes using ANOVA.
Main Results:
- On day 1, significant leptin concentration changes were observed (ANOVA, p<0.05), with a 44% increase around noon and a 7% decrease in the morning.
- On day 3, no significant changes in leptin concentration were detected (ANOVA, p=0.79).
Conclusions:
- Critically ill heart failure patients exhibit preserved circadian leptin rhythm on the first day of admission.
- Circadian leptin rhythmicity is lost by the third day in these patients.
- Disruption of circadian leptin regulation may occur as critical illness progresses.
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