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Triterpenoids and lignans from the stems of Schisandra glaucescens
Wenming Wu1,2, Hanli Ruan1
1a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Abstract:
Two new triterpenoids, 24( E)-3 α,12 α-dihydroxyl-lanost-9(11),24-dien-26-oid acid (1) and 3,4- seco-24( Z)-6 α,7 β-dihydroxyl-cycloart-4(28),24-dien-3,26-dioic-3-methyl ester (2), and ten known ones (3-12), together with eight lignans (13-20), were isolated from the stems of Schisandra glaucescens. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1-3, 5-7, 9, 11-13 and 15-18 were isolated from this species for the first time. 1 and 2 were evaluated for their in vitro cytotoxicities against the mouse cancer B16 cell line, human cancer HepG2 and MCF7 cell lines by MTT assay.
