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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Recent advances in anti-angiogenic nanomedicines for cancer therapy
Pravin Bhattarai1, Sadaf Hameed1, Zhifei Dai1
1Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. zhifei.dai@pku.edu.cn.
Abstract:
Angiogenesis is a normal physiological remodeling process initiated at the time of embryonic development and lessened with the progress of time. Nevertheless, continuous activation of stringent signaling pathways and proangiogenic factors during tumorigenesis (a pathological condition) instigates serious vessel abnormalities eliciting severe therapeutic inefficiency. In principle, systemic delivery of robust antiangiogenic drugs often fails to reach these abnormal tumor vessels depicting poor pharmacokinetics, biodistribution profiles and adverse side effects in vivo. Recently, the advent of nanotechnology has offered numerous advantages encompassing high drug payloads, increased blood half-life and reduced toxicity; likewise, such nanomedicines can also target the key components of the tumor microenvironment and tumor cells effectively. Synergistic targeting of malignant cells and vessel abnormalities via integration of antiangiogenic and other potent combinational regimens in a single nanoplatform can revitalize therapeutic success. In this review, we will discuss the most promising nanotechnological advancements rehabilitating angiogenesis, and emerging nanocarriers comprehending gene delivery, stem cell therapies and dynamic combinational strategies for effective anticancer therapy.
Insights
Nanotechnology offers new ways to fight cancer by improving drug delivery and targeting abnormal tumor vessels. Combining antiangiogenic therapies with nanomedicine can enhance treatment effectiveness and reduce side effects.
Area of Science:
- Oncology
- Nanomedicine
- Biotechnology
Background:
- Angiogenesis, a normal process, becomes abnormal during tumorigenesis, leading to ineffective cancer therapies.
- Conventional antiangiogenic drugs face challenges in reaching tumor vessels due to poor pharmacokinetics and biodistribution.
- Tumor microenvironment and malignant cells require targeted therapeutic strategies for improved outcomes.
Purpose of the Study:
- To review advancements in nanotechnological applications for rehabilitating aberrant angiogenesis in cancer.
- To explore emerging nanocarriers for gene delivery, stem cell therapies, and combination strategies.
- To highlight the potential of synergistic nanomedicine in overcoming therapeutic inefficiencies in cancer treatment.
Main Methods:
- Review of current literature on nanotechnology in cancer angiogenesis.
- Analysis of nanocarrier systems for drug delivery and targeting.
- Discussion of gene delivery, stem cell therapy, and combination regimens within nanoplatforms.
Main Results:
- Nanotechnology provides advantages like high drug payloads, extended blood half-life, and reduced toxicity.
- Nanomedicines can effectively target tumor microenvironment components and cancer cells.
- Synergistic approaches integrating antiangiogenic and other therapies on a single nanoplatform show promise.
Conclusions:
- Nanotechnology-based strategies hold significant potential for overcoming limitations in antiangiogenic cancer therapy.
- Emerging nanocarriers and combination therapies are crucial for revitalizing therapeutic success.
- Targeted delivery and synergistic action of nanomedicines offer a promising avenue for effective anticancer treatment.
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