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Related Concept Videos

Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
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Related Experiment Video

Updated: Feb 13, 2026

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
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Multifunctional Surface Modification of Nanodiamonds Based on Dopamine Polymerization.

Yun Zeng, Wenyan Liu, Zheyu Wang1

  • 1Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering , Washington University in St. Louis , St Louis , Missouri 63130 , United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 13, 2018
PubMed
Summary

This study presents a new method for functionalizing nanodiamonds (NDs) using dopamine polymerization. This approach simplifies the creation of ND-based nanoconjugates for advanced material and therapeutic applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Surface functionalization of nanodiamonds (NDs) is crucial for advanced material and therapeutic applications.
  • Challenges in ND surface modification include complex surface chemistry and low functional group density.
  • Existing methods often struggle with stability and versatility in creating ND nanoconjugates.

Purpose of the Study:

  • To develop a general and robust surface functionalization approach for nanodiamonds.
  • To create stable ND-based core-shell nanoconjugates with diverse functionalities.
  • To demonstrate the versatility of the functionalization method for various applications.

Main Methods:

  • Utilized dopamine polymerization for surface functionalization of nanodiamonds.
  • Leveraged the universal adhesion and reactivity of polydopamine.
  • Conjugated DNA and silver nanoparticles onto the functionalized nanodiamonds.

Main Results:

  • Successfully prepared ND-based core-shell nanoconjugates.
  • Demonstrated effective conjugation of DNA and silver nanoparticles onto ND surfaces.
  • Validated the catalytic activity of silver nanoparticle-supported NDs and the addressability of DNA-conjugated NDs.

Conclusions:

  • The dopamine polymerization method provides a simple and robust approach for ND surface functionalization.
  • This technique significantly enhances the capability for attaching various functionalities onto NDs.
  • Opens new platforms for diverse applications of functionalized nanodiamonds.