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Calcium Phosphate Transfection of Primary Hippocampal Neurons
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Calcium phosphate-based nanosystems for advanced targeted nanomedicine
Lorenzo Degli Esposti1, Francesca Carella1, Alessio Adamiano1
1a Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR) , Faenza , Italy.
Drug Development and Industrial Pharmacy
|March 13, 2018
Summary
Synthetic calcium phosphates (CaPs) nanoparticles show promise in nanomedicine for targeted drug delivery. Active targeting strategies enhance specificity, minimizing off-target effects for improved therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Nanomedicine
- Materials Science
Background:
- Synthetic calcium phosphates (CaPs) are established bioceramics for bone repair.
- Advancements enable CaPs nanoparticles with controlled dimensions, surface properties, and stability.
- CaPs nanoparticles are emerging as versatile carriers in nanomedicine.
Purpose of the Study:
- To review advanced targeted nanomedicine systems.
- To focus on recent developments in CaP nanoparticles for active targeting.
- To discuss the unique properties of CaP nanoparticles in nanomedicine.
Main Methods:
- Review of recent literature on CaP nanoparticles in targeted nanomedicine.
- Analysis of active targeting strategies for CaP nanoparticles.
- Comparison of CaP nanoparticles with other nanomaterials for nanomedicine applications.
Main Results:
- CaP nanoparticles can be engineered for specific disease site targeting.
- Active targeting, via conjugation with targeting moieties, enhances specificity and efficacy.
- CaP nanoparticles offer distinct advantages over other nanomaterials for targeted applications.
Conclusions:
- CaP nanoparticles represent a promising platform for targeted drug and imaging agent delivery.
- Active targeting significantly improves the precision of nanomedicine interventions.
- CaP nanoparticles possess unique characteristics that make them highly suitable for advanced nanomedical applications.
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