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The effects of treatment with atorvastatin versus rosuvastatin on endothelial dysfunction in patients with
Vahit Demir1, Mehmet Tolga Doğru2, Hüseyin Ede1
1Cardiology Department, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Insights
Atorvastatin and rosuvastatin both improved endothelial function in hyperlipidaemic patients over one year. The extent of improvement in endothelial function was similar between the two statin treatments.
Area of Science:
- Cardiology
- Pharmacology
- Vascular Biology
Background:
- Statins are crucial for reducing cardiovascular events and enhancing endothelial function.
- Existing research has not sufficiently explored the comparative effects of different statins on endothelial dysfunction.
- Endothelial dysfunction is a key factor in the development of atherosclerosis and cardiovascular disease.
Purpose of the Study:
- To compare the efficacy of atorvastatin versus rosuvastatin in improving endothelial function.
- To assess the impact of these statins on both flow-mediated dilation (endothelium-dependent) and nitrate-mediated dilation (endothelium-independent).
Main Methods:
- A one-year study involving hyperlipidaemic subjects treated with either atorvastatin (20 mg/day) or rosuvastatin (10 mg/day).
- Endothelial function was evaluated using ultrasonography to measure flow-mediated dilation (FMD) and endothelium-independent dilation (EID).
- Baseline and final measurements of FMD and EID were compared within and between the treatment groups.
Main Results:
- Both atorvastatin and rosuvastatin groups showed significant improvements in FMD and EID from baseline to final measurements.
- The mean changes in FMD and EID were statistically similar between the atorvastatin and rosuvastatin groups (p > 0.05 for both).
- No significant differences were observed in the final FMD and EID values between the two statin treatment groups.
Conclusions:
- One-year treatment with atorvastatin and rosuvastatin effectively improves endothelial function.
- The degree of improvement in endothelial function is comparable between atorvastatin and rosuvastatin.
- These findings suggest that both statins are similarly effective in addressing endothelial dysfunction in hyperlipidaemic patients.
Introduction:
Statins can reduce cardiovascular events and improve endothelial function. However, differences in the effect of statins on endothelial dysfunction have not been researched sufficiently. Here, we aimed to compare the effects of atorvastatin versus rosuvastatin on endothelial function via flow-mediated and endothelial-independent dilation.
Methods:
Hyperlipidaemic subjects on treatment with statins for one year (either 20 mg/day atorvastatin or 10 mg/day rosuvastatin) were enrolled in the study. In accordance with the literature, flow-mediated dilation (FMD) and nitrate-mediated endothelium-independent dilation (EID) were measured by ultrasonography on the right brachial artery of each subject. Baseline and final measurements were compared in each group and between the groups.
Results:
One hundred and four subjects (50 atorvastatin and 54 rosuvastatin users) were enrolled in the study. Fifty-eight subjects were female. The groups were statistically similar in terms of age and body mass index, and haemoglobin, creatinine, total cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein cholesterol levels. In each group, the mean final FMD and EID values were higher compared to their respective baseline values, but the mean changes in FMD and EID were statistically similar in both groups (p = 0.958 for FMD and 0.827 for EID). There was no statistically significant difference between the atorvastatin and rosuvastatin groups in terms of final FMD and EID values (p = 0.122 and 0.115, respectively).
Conclusions:
This study demonstrated that both one-year atorvastatin and rosuvastatin treatments significantly improved endothelial function, when assessed with FMD and EID and measured by ultrasonography. However, the amount of improvement in endothelial dysfunction was similar in the two treatments.
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