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Related Experiment Videos

Immunologic dysfunction: simultaneous study of Alzheimer's and older Down's patients.

V K Singh, H H Fudenberg, F R Brown

    Mechanisms of Ageing and Development
    |January 1, 1986
    PubMed
    Summary

    Cellular immune function is impaired in Alzheimer's disease and Down's syndrome. Lymphocyte DNA synthesis was significantly reduced in both patient groups compared to healthy individuals, indicating immune deficits.

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    Area of Science:

    • Immunology
    • Neuroscience
    • Genetics

    Background:

    • Alzheimer's disease (AD) and Down's syndrome (DS) share pathological features.
    • Immune system dysregulation may contribute to neurodegeneration in both conditions.

    Purpose of the Study:

    • To investigate cellular immune function in patients with Alzheimer's disease and Down's syndrome.
    • To compare lymphocyte DNA synthesis and T cell populations between patient groups and healthy controls.

    Main Methods:

    • In vitro lymphocyte DNA synthesis assays using phytohemagglutinin, pokeweed mitogen, and OKT3 antibody.
    • Quantification of T cells expressing surface membrane orosomucoid.

    Main Results:

    • Significantly decreased lymphocyte DNA synthesis in response to mitogens and antibody in both AD and DS patients compared to controls.

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  • Autologous mixed lymphocyte reaction (AMLR) showed no significant difference between groups.
  • Altered orosomucoid expression on T cells observed in DS patients, but not in AD patients.

    • Conclusions:

    • Elderly patients with Down's syndrome and Alzheimer's disease exhibit defective cellular immune functions.
    • These findings suggest a role for immune system impairment in the pathogenesis of both conditions.