![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Palladium-Catalyzed Seven-Membered Silacycle Construction: 1,7-Enyne Hydroxycyclization To Give a Benzosilepine
Kohei Takamoto1, Shohei Yoshioka1, Hiromichi Fujioka1
1Graduate School of Pharmaceutical Sciences , Osaka University , Yamada-oka 1-6 , Suita , Osaka 565-0871 Japan.
Organic Letters
|March 13, 2018
Abstract:
A palladium-catalyzed hydroxycyclization reaction of 1,7-enynes to afford seven-membered silacycles (1 H-benzo[ b]silepine skeletons) is developed. This is the first example of both seven-membered ring construction from enynes using a palladium catalyst and hydroxycyclization of enynes to give seven-membered silacycles.
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