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Echocardiographic assessment of left ventricular morphology and function in patients with fibromuscular dysplasia:

Piotr Dobrowolski1, Magdalena Januszewicz2,3, Anna Klisiewicz1

  • 1Department of Congenital Heart Diseases.

Journal of Hypertension
|March 13, 2018
PubMed
Abstract

Insights

Fibromuscular dysplasia (FMD) does not alter left ventricle (LV) structure or function, even with renal artery stenosis. This study found no significant cardiac differences between FMD patients and controls.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Echocardiography

Background:

  • Fibromuscular dysplasia (FMD) is a vascular disease that can lead to hypertension and other complications.
  • The impact of FMD on cardiac structure and function, particularly the left ventricle (LV), requires comprehensive assessment.

Purpose of the Study:

  • To assess LV structure and function in patients with FMD.
  • To identify potential alterations in cardiac properties related to FMD presence, subtypes, and extent.
  • To compare cardiac parameters between FMD patients and a matched control group.

Main Methods:

  • 144 patients with FMD and 50 controls underwent echocardiography.
  • Evaluated left ventricular mass index (LVMI), systolic function (speckle tracking), and diastolic function (mitral flow, tissue Doppler).
  • Office and ambulatory blood pressure levels were also assessed.

Main Results:

  • No significant differences in LV morphology or function were observed between FMD patients and controls.
  • No differences in LVMI or systolic function were found between unifocal and multifocal renal FMD.
  • Multifocal FMD showed lower early diastolic velocity (e'), but this was not independently correlated with FMD in multivariate analysis.

Conclusions:

  • Unlike atherosclerotic renal artery stenosis, FMD does not appear to alter LV morphology or function.
  • Despite potential hypertension and vascular complications, FMD does not demonstrate a direct impact on the left ventricle.
  • Further research may explore subtle diastolic function changes in specific FMD subtypes.

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