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Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
Published on: June 7, 2017
Gottesfeld-Hohler Memorial Foundation Zika Virus Think Tank Summary
John C Hobbins1, Lawrence D Platt, Joshua A Copel
1Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, Colorado; the Departments of Obstetrics, Gynecology and Reproductive Sciences and Pediatrics, Yale School of Medicine, New Haven, Connecticut; the Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California; the Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Texas Children's Hospital, Baylor College of Medicine, Department of Obstetrics and Gynecology, Houston, Texas; Maternal-Fetal Medicine, Eastern Virginia School of Medicine, Norfolk, Virginia; Obstetrics and Gynecology, University of California, San Francisco, San Francisco, California; North Florida Women's Physicians, Gainesville, Florida; Maternal Fetal Medicine Department, Colsanitas Clinic, Columbia University Clinic, Bogota, Colombia; Maternal Fetal Medicine and Gynecology, San Juan, Puerto Rico; Professor Joaquim Amorim Neto Research Institute, Campina Grande, Brazil; Johns Hopkins University/Jhpiego and Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland; The Federal University of Rio de Janeiro, Brazil; and the American Institute of Ultrasound in Medicine, Laurel, Maryland.
Zika virus infection in fetuses presents diverse neuroimaging findings, influenced by infection timing and host factors. Resource availability for diagnosis and intervention varies globally, highlighting needs for research and clinical collaboration.
Area of Science:
- Neuroimaging
- Obstetric Infectious Diseases
- Public Health
Background:
- Zika virus (ZIKV) poses significant risks to fetal development.
- Understanding ZIKV's impact requires interdisciplinary expertise.
Discussion:
- Fetal neuroimaging reveals varied abnormalities in ZIKV-affected pregnancies.
- Infection timing and host factors likely modulate imaging presentation.
- Disparities in diagnostic and intervention resources exist globally.
Key Insights:
- ZIKV infection leads to a spectrum of fetal brain abnormalities.
- Geographical resource inequality impacts ZIKV care.
- Collaboration is crucial for advancing ZIKV research and clinical management.
Outlook:
- Continued research is needed to elucidate ZIKV's pathogenesis.
- Enhanced global collaboration can improve outcomes for affected pregnancies.
- Public health strategies must address resource limitations in vulnerable regions.
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