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Updated: Feb 13, 2026
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome
Sara M Drayer1, Larry R Laufer, Maureen E Farrell
1Departments of Obstetrics and Gynecology and Reproductive Endocrinology and Infertility, Naval Medical Center San Diego, San Diego, California.
Obstetrics and Gynecology
|March 13, 2018
Summary
Autoimmune progesterone dermatitis causes cyclical skin issues linked to progesterone levels. Surgical treatment like oophorectomy may be necessary when medical management fails for this rare condition.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Autoimmune progesterone dermatitis is a rare condition characterized by cyclical skin eruptions.
- Symptoms correlate with the luteal phase of the menstrual cycle, triggered by rising progesterone levels.
Purpose of the Study:
- To present a case of refractory autoimmune progesterone dermatitis.
- To discuss diagnostic and treatment challenges of this uncommon disease.
Main Methods:
- Diagnosis was confirmed via intradermal progesterone challenge.
- The patient underwent bilateral oophorectomy after 48 months of refractory disease.
Main Results:
- The patient's autoimmune progesterone dermatitis was refractory to medical management.
- Surgical intervention with bilateral oophorectomy provided a definitive treatment.
Conclusions:
- Autoimmune progesterone dermatitis presents diagnostic challenges due to its rarity and varied clinical manifestations.
- Treatment involves progesterone suppression and trigger avoidance; surgical management is considered for refractory cases.
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