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Echocardiographic reference ranges for normal left atrial function parameters: results from the EACVI NORRE study.

Tadafumi Sugimoto1, Sébastien Robinet1, Raluca Dulgheru1

  • 1Department of Cardiology, University of Liège Hospital, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU du Sart Tilman, Domaine Universitaire du Sart Tilman, Batiment B35, 4000 Liège, Belgium.

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This study establishes normal echocardiographic ranges for left atrial (LA) function in healthy adults. Age-specific values are crucial, as LA reservoir and conduit functions decrease with age, while pump function increases.

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Area of Science:

  • Cardiovascular Imaging
  • Echocardiography
  • Cardiac Physiology

Background:

  • Left atrial (LA) function is critical for cardiac health.
  • Establishing normal reference ranges is essential for accurate diagnosis.
  • Previous studies lacked large, multi-center data accounting for demographics.

Purpose of the Study:

  • To determine normal ranges for echocardiographic measurements of LA function.
  • To account for age and gender in LA function reference values.
  • To provide updated, applicable reference ranges for clinical use.

Main Methods:

  • Analysis of 371 healthy subjects from the NORRE study (European Association of Cardiovascular Imaging).
  • Utilized vendor-independent software (VIS) for homogeneous LA data analysis.
  • Measured left atrial strain (LAS), LA emptying fraction (LAEF), and LA strain rate (SRa) for reservoir, conduit, and pump functions.

Main Results:

  • Defined lowest expected values for LA reservoir, conduit, and pump functions.
  • Demonstrated age-related decreases in LA reservoir and conduit function.
  • Observed age-related increases in LA pump function; no significant gender or vendor differences in most indices, except LA SRa.

Conclusions:

  • The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function.
  • Age-specific reference values for LA function are essential for accurate interpretation.
  • These findings support improved clinical assessment of cardiac health.