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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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BioPepDB: an integrated data platform for food-derived bioactive peptides.

Qilin Li1, Chao Zhang2, Hongjun Chen1

  • 1a Department of Bioinformatics, College of Life Sciences , Zhejiang University , Hangzhou , China.

International Journal of Food Sciences and Nutrition
|March 14, 2018
PubMed
Summary

BioPepDB is a new searchable database for food-derived bioactive peptides, integrating over 4,000 entries. It aids in discovering novel peptides and understanding their functions.

Keywords:
Bioactive peptidedatabasehydrolysis simulationsequence prediction

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Food Science

Background:

  • Food-derived bioactive peptides are crucial for biological regulation, with significant medical and industrial applications.
  • Existing data on bioactive peptides is fragmented, hindering comprehensive research and discovery.
  • A centralized, integrated resource is needed to consolidate information on food-derived bioactive peptides.

Purpose of the Study:

  • To develop BioPepDB, a comprehensive, searchable database of food-derived bioactive peptides.
  • To provide tools for predicting and simulating novel bioactive peptides.
  • To serve as a reference for investigating bioactive peptide functions.

Main Methods:

  • Curated data from scientific literature on food-derived bioactive peptides.
  • Development of a searchable database using Apache, PHP5, and MySQL.
  • Implementation of prediction and hydrolysis-simulation modules for novel peptide discovery.

Main Results:

  • BioPepDB contains over 4,000 entries of food-derived bioactive peptides.
  • The database integrates peptide sequence, function, source, and commercial information.
  • Prediction and simulation modules are available for discovering new bioactive peptides.

Conclusions:

  • BioPepDB offers a valuable, integrated resource for researchers studying food-derived bioactive peptides.
  • The database facilitates the discovery and functional investigation of novel bioactive peptides.
  • BioPepDB supports advancements in the biological, medical, and industrial applications of bioactive peptides.