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Related Concept Videos

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
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Related Experiment Video

Updated: Feb 13, 2026

Microinjection of Western Corn Rootworm, Diabrotica virgifera virgifera, Embryos for Germline Transformation, or CRISPR/Cas9 Genome Editing
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Why Human Germline Editing is More Problematic than Selecting Between Embryos: Ethically Considering

Christoph Rehmann-Sutter1

  • 1a Institute of History of Medicine and Science Studies , University of Lübeck , Lubeck , Germany.

The New Bioethics : a Multidisciplinary Journal of Biotechnology and the Body
|March 14, 2018
PubMed
Summary
This summary is machine-generated.

There is no moral obligation for human germline gene editing (hGGE) to cure embryos. This ethical analysis argues against hGGE, finding it complicates intergenerational relationships more than pre-implantation genetic diagnosis (PGD).

Keywords:
gene therapygermlinegermline gene editingintergenerational relationshipsphenomenology of reproductive genetics

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Area of Science:

  • Bioethics
  • Human Germline Gene Editing (hGGE)
  • Reproductive Technologies

Background:

  • The ethical debate surrounding human germline gene editing (hGGE) often centers on a potential moral obligation to cure genetic conditions.
  • Pre-implantation genetic diagnosis (PGD) offers an alternative by selecting embryos unaffected by certain genetic diseases.
  • The concept of the germline extends beyond mere genetic information, encompassing intergenerational relationships and familial connections.

Purpose of the Study:

  • To critically evaluate the ethical intuition that a moral obligation exists to genetically cure embryos using hGGE.
  • To develop a theoretical framework for analyzing the ethics of hGGE, considering its impact on intergenerational relationships.
  • To compare the ethical implications of gene editing versus embryo selection (PGD).

Main Methods:

  • Development of a theoretical framework based on the phenomenology of the germline from biological and philosophical perspectives.
  • Analysis of the germline as an embodied intergenerational relationship.
  • Comparative ethical analysis of hGGE and PGD, focusing on parental and future child responsibilities.

Main Results:

  • hGGE involves co-constructing the genome, imposing broader responsibilities than PGD.
  • hGGE significantly alters the moral structure of intergenerational relationships.
  • The claim that hGGE is in the best interest of the child is counterfactual; future children may prefer not to have been treated.

Conclusions:

  • There is no moral obligation to pursue hGGE for curing genetic conditions.
  • hGGE introduces complexities and burdens into intergenerational relationships.
  • PGD, based on selecting unaffected embryos, is ethically distinct from hGGE.